تفاعل #1727440

معادلة التفاعل

2-chloroisonicotinic acid

4,5-difluoroindoline-hydrochloride

TBTU

potassium carbonate

→

(2-chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe precipitate formed
2. 2
   ترشيحfiltered
3. 3
   غسيلwashed with water
4. 4
   أخرىdried

الإجراء التجريبي

0.50 g (3.2 mmol) 2-chloroisonicotinic acid, 0.63 mg (3.3 mmol) 4,5-difluoroindoline-hydrochloride, 0.91 mL (6.5 mmol) TEA and 1.1 g (3.4 mmol) TBTU in 10 mL DMF were stirred overnight at RT. Then the reaction mixture was poured onto 200 mL of 15% potassium carbonate solution, the precipitate formed was suction filtered, washed with water and dried.

المصدر