تفاعل #1726706

معادلة التفاعل

2-(N-Boc-amino)-3-phenyl-thiophene

N-chlorosuccinimide

→

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

المردود 66.6%

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىat 0° C.
2. 2
   غسيلwashed with water
3. 3
   تركيزthe organic phase concentrated in vacuo

الإجراء التجريبي

To 2-(N-Boc-amino)-3-phenyl-thiophene (89 mg, 0.32 mmol) in dichloromethane (4 ml) at 0° C. was slowly added N-chlorosuccinimide (48 mg, 0.36 mmol), and the mixture allowed warm to ambient temperature for 16 hr. The mixture was diluted with dichloromethane, washed with water, and the organic phase concentrated in vacuo. Flash chromatography on silica gel (ethyl acetate/hexanes) yielded 2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene (66 mg, 66%).

المصدر