تفاعل #1726705

معادلة التفاعل

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole

phosphoric acid

ammonium hydroxide

→

5-amino-1-(3′-nitrophenyl)-pyrazole

المردود 80.0%

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe organics were extracted three times with diethyl ether (total 40 ml)
2. 2
   غسيلwashed with brine
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   أخرىRemoval of solvent

الإجراء التجريبي

5-amino-1-(3′-nitrophenyl)-4-cyanopyrazole (559 mg, 2.44 mmol) and phosphoric acid (86%, 6 ml) were refluxed at 170° C. for 15 h. The reaction was cooled to room temperature and neutralized with ammonium hydroxide. The organics were extracted three times with diethyl ether (total 40 ml), washed with brine, and dried over magnesium sulfate. Removal of solvent gave 5-amino-1-(3′-nitrophenyl)-pyrazole as a yellow powder (398 mg, 80% yield).

المصدر