تفاعل #172545

معادلة التفاعل

2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoic acid

ethyl 2-hydroxybenzoate

DCC

→

ethyl 2-(2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoyloxy)benzoate

المردود 67.0%

المذيبات

CH3CN THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىThe crude product was purified by silica gel chromatography (EtOAc-PE, 0-20%)

الإجراء التجريبي

To a solution of 2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoic acid (50 mg, 0.11 mmol) and ethyl 2-hydroxybenzoate (19 mg, 0.11 mmol) in CH3CN/THF (1:1, 0.5 mL) at −10° C. was added DCC (12 mg, 0.11 mmol) and DMAP (1 mg). The mixture was stirred (RT, 16 h), filtered and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (EtOAc-PE, 0-20%) to afford ethyl 2-(2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoyloxy)benzoate (40 mg, 67%) as colorless oil. Mass calculated for C37H51NO5=589.80; found: [M+H]+=590.4.

المصدر