تفاعل #172338

معادلة التفاعل

K2CO3

NaI

(6-(tert-butoxycarbonylamino)pyridin-3-yl)methyl methanesulfonate

benzyl piperazine-1-carboxylate

→

benzyl 4-((6-(tert-butoxycarbonylamino)pyridin-3-yl)methyl)piperazine-1-carboxylate

المردود 96.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered
2. 2
   تركيزthe filtrate was concentrated under reduced pressure
3. 3
   workup.ADDITIONWater (30 mL) was added
4. 4
   ترشيحthe mixture was filtered
5. 5
   غسيلThe collected solids were washed further with water
6. 6
   أخرىdried

الإجراء التجريبي

A mixture of (6-(tert-butoxycarbonylamino)pyridin-3-yl)methyl methanesulfonate (102; 1.30 g, 5.4 mmol), benzyl piperazine-1-carboxylate 103; (1.42 g, 6.5 mmol), K2CO3 (2.30 g, 16.1 mmol) and NaI (0.08 g, 0.54 mmol) in DMF (20 mL) was stirred at 60° C. for 2 h. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. Water (30 mL) was added and the mixture was filtered. The collected solids were washed further with water and dried to afford benzyl 4-((6-(tert-butoxycarbonylamino)pyridin-3-yl)methyl)piperazine-1-carboxylate 104 (2.20 g, 96%).

المصدر