تفاعل #1723

معادلة التفاعل

sodium chloride

4-ethynylbenzonitrile

2-bromo-5-nitrothiophene

triethylamine

→

4-[(5-nitro-2-thienyl)ethynyl]benzonitrile

المذيبات

ethyl acetate

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   تجفيفThe organic layer was dried over anhydrous sodium sulfate
2. 2
   ترشيحfiltered
3. 3
   أخرىevaporated to dryness
4. 4
   أخرىThe crude solid was triturated with 1:1 dichloromethane/hexane

الإجراء التجريبي

To a solution of 4-ethynylbenzonitrile (0.5 g), 2-bromo-5-nitrothiophene (0.9 g) and bis(triphenylphosphine)palladium dichloride (83 mg) in anhydrous dimethylformamide (4 ml) was added triethylamine (2.2 ml). The reaction mixture was stirred at room temperature for 3 days then ethyl acetate (200 ml) and saturated sodium chloride (200 ml) were added. The organic layer was dried over anhydrous sodium sulfate, filtered and evaporated to dryness. The crude solid was triturated with 1:1 dichloromethane/hexane followed by diethyl ether to give 4-[(5-nitro-2-thienyl)ethynyl]benzonitrile as a yellow solid.

المصدر