تفاعل #172298

معادلة التفاعل

2,3-diaminobenzoic acid

tert-butyl 3-(2-formylphenoxy)pyrrolidine-1-carboxylate

Na2S2O5

sodium metabisulfite

→

titled compound 31

المردود 84.4%

2-(2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yloxy)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid

المردود 84.4%

المذيبات

DMF

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was cooled to room temperature
2. 2
   workup.STIRRINGstirred for 1 h
3. 3
   ترشيحfiltered
4. 4
   غسيلwashed with water
5. 5
   أخرىThe filter cake was dried under vacuum

الإجراء التجريبي

A mixture of 2,3-diaminobenzoic acid (1; 350 mg, 2.3 mmol), tert-butyl 3-(2-formylphenoxy)pyrrolidine-1-carboxylate (30; 670 mg, 2.3 mmol) and Na2S2O5 (568 mg, 1.3 mmol) in DMF (30 mL) was stirred at 90° C. for 18 h. The mixture was cooled to room temperature. The mixture was diluted with water (100 mL), stirred for 1 h, filtered, and washed with water. The filter cake was dried under vacuum to afford 822 mg of the titled compound 31 (84%). MS (ESI) calcd for C23H25N3O5: 423.18; found: 424 [M+H].

المصدر