تفاعل #171874

معادلة التفاعل

2-((2,4-difluorophenyl)(methyl)carbamoyl)-4H-thieno[3,2-c]chromene-8-carboxylic acid

dimethylamine

→

N2-(2,4-difluorophenyl)-N2,N8,N8-trimethyl-4H-thieno[3,2-c]chromene-2,8-dicarboxamide

ظروف التفاعل

المعالجة

1. 1
   أخرىto give 111bp

الإجراء التجريبي

Following the procedure of Example 15 and General Procedure C, 2-((2,4-difluorophenyl)(methyl)carbamoyl)-4H-thieno[3,2-c]chromene-8-carboxylic acid and dimethylamine were coupled to give 111bp. 1H NMR (400 MHz, CDCl3) δ 7.15-7.31 (m, 3 H), 6.82-7.00 (m, 4 H,), 5.13 (s, 2 H), 3.33 (m, 3 H), 2.94-3.13 (m, 6 H). LCMS (ESI) m/z: 429.1.

المصدر