تفاعل #171315

معادلة التفاعل

1-(3-fluorophenyl)-3,4-dihydroisoquinoline

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crystalline solid

المردود 100.2%

1-(3-Fluorophenyl)isoquinoline

المردود 100.2%

المذيبات

o-dichlorobenzene

ظروف التفاعل

المعالجة

1. 1
   ترشيحSubsequently, the reaction solution was filtered through Celite which
2. 2
   غسيلwas rinsed with dichloromethane/ethanol (25:1)
3. 3
   workup.DISTILLATIONSubsequently, the solvent was distilled off under reduced pressure

الإجراء التجريبي

266.41 g (1.183 mol) of 1-(3-fluorophenyl)-3,4-dihydroisoquinoline were dissolved in 1500 ml of o-dichlorobenzene and admixed with 901.2 g (10.37 mol, 8.7 eq.) of manganese. The mixture was stirred at 160-170° C. for 16 h. Subsequently, the reaction solution was filtered through Celite which was rinsed with dichloromethane/ethanol (25:1). Subsequently, the solvent was distilled off under reduced pressure. 264.74 g of a crystalline solid with 99% purity were obtained, corresponding to 99% of theory.

المصدر