تفاعل #171097

معادلة التفاعل

5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

K2CO3

5-bromo-2-(bromomethyl)-1,3-difluorobenzene

→

2-(4-bromo-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

المردود 87.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   تركيزThe filtrate was concentrated under reduced pressure
3. 3
   أخرىpurified by chromatography (10% MeOH/DCM)

الإجراء التجريبي

To a mixture of 5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol (1.00 g, 2.65 mmol) and K2CO3(0.51 g, 3.70 mmol) in acetone (13 mL) was added 5-bromo-2-(bromomethyl)-1,3-difluorobenzene (0.91 g, 3.18 mmol). The reaction mixture was stirred 1 h and then filtered. The filtrate was concentrated under reduced pressure and purified by chromatography (10% MeOH/DCM) to yield 2-(4-bromo-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole as a tan solid (1.34 g, 87%). MS (EI) m/z 581 (MH+).

المصدر