تفاعل #170960

معادلة التفاعل

4-nitrophenol

K2CO3

methyl chloroacetate

→

7

المردود 72.5%

Methyl (4-Nitro phenoxy)acetate

المردود 72.5%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 12 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (1500 ml) was added
4. 4
   ترشيحCrude 7 was filtered
5. 5
   أخرىdried
6. 6
   أخرىrecrystallised from a mixture of ethyl acetate:hexane (1:5)

الإجراء التجريبي

To a mixture of 4-nitrophenol (100 g, 719 mmol) and anhydrous K2CO3 (400 gm, 2.894 mol) in anhydrous acetone (950 ml) was added methyl chloroacetate (114 g, 1.050 moles) and refluxed for 12 hours. Acetone was distilled off and water (1500 ml) was added. Crude 7 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 7 (110 g, 72.5%) as a white fluffy powder with an m.p between 97-98.4° C.

المصدر