تفاعل #170523

ord-1f79af4c6aa64cda9735517091a3e5e0

معادلة التفاعل

Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)O)cn1
6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid
CC1CCCN1
2-methyl-pyrrolidine
Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)N2CCCC2C)cn1
title compound
المردود 99.0%
Cc1onc(-c2ccccc2)c1COc1ccc(C(=O)N2CCCC2C)cn1
[6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-(2-methyl-pyrrolidin-1-yl)-methanone
المردود 99.0%

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.64 mmol) was converted, using 2-methyl-pyrrolidine instead of 2-aminoethyl isopropylether, to the title compound (240 mg, 99%) which was obtained as a colourless. MS: m/e=378.3 [M+H]+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08846719B2uspto-grants-2014_09