تفاعل #170278

معادلة التفاعل

TFA

1-hydroxy-5-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one

→

title compound

المردود 47.3%

3-(2,3-dihydroxypropoxy)-1-hydroxy-5-methoxy-9H-xanthen-9-one

المردود 47.3%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed
2. 2
   أخرىthe resulting residue was dried under reduced pressure

الإجراء التجريبي

50% TFA (5 mL) was added to 1-hydroxy-5-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (20 mg, 0.06 mmol) synthesized in Step 2 of Example 1, and the reaction mixture was stirred at 50° C. for 4 hours. The solvent was removed, and the resulting residue was dried under reduced pressure to give the title compound (10 mg, 47.3%) as a white solid.

المصدر