تفاعل #170273

معادلة التفاعل

HCl

1-hydroxy-5-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one

→

title compound

المردود 92.0%

3-(3-chloro-2-hydroxypropoxy)-1-hydroxy-5-methoxy-9H-xanthen-9-one

المردود 92.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction solvent was removed under reduced pressure
2. 2
   workup.ADDITIONEther was added to the residue
3. 3
   أخرىfollowed by sonication
4. 4
   أخرىthe solvent was removed

الإجراء التجريبي

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-hydroxy-5-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (30 mg, 0.10 mmol) synthesized in Step 2 of Example 1, followed by stirring at room temperature for 30 minutes, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to obtain the title compound (31 mg, 92%) as a light brown solid.

المصدر