تفاعل #1702080

معادلة التفاعل

dichloromethane

acetone

5-cyclopropyl-1-(2-(4-fluorophenyl)-2-oxoethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

sodium borohydride

→

desired product

المردود 46.0%

5-cyclopropyl-1-(2-(4-fluorophenyl)-2-hydroxyethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one

المردود 46.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   غسيلThe resulting solution was washed with water
2. 2
   تجفيفthe organic phase was dried over sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   أخرىEvaporation

الإجراء التجريبي

To a solution of 5-cyclopropyl-1-(2-(4-fluorophenyl)-2-oxoethyl)-8-methoxy-2,3,5,6-tetrahydrobenzo[b][1,5]diazocin-4(1H)-one (65.0 mg, 0.170 mmol) from Example 5 in ethanol (1 ml) was added sodium borohydride (6.4 mg, 0.170 mmol) and the reaction mixture was stirred at room temperature over weekend. Then was added acetone (0.062 ml) followed by dilution with dichloromethane. The resulting solution was washed with water and the organic phase was dried over sodium sulfate and filtered. Evaporation gave the desired product (30 mg, 46%).

المصدر