تفاعل #1702077

معادلة التفاعل

diethylether

2-(4-chlorophenyl)ethanol

Dess-Martin periodinane

→

desired compound

المردود 42.2%

2-(4-chlorophenyl)acetaldehyde

المردود 42.2%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلthe resulting mixture was washed with a 1:1 solution (150 ml) of sodium carbonate (aqueous saturated) and sodium thiosulfate (aqueous saturated)
2. 2
   تجفيفThe organic phase was then dried over sodium sulfate
3. 3
   أخرىevaporated

الإجراء التجريبي

To a solution of 2-(4-chlorophenyl)ethanol (2.00 g, 12.77 mmol) in dichloromethane (100 ml) was added Dess-Martin periodinane (8.12 g, 19.16 mmol) and the mixture was stirred at room temperature over weekend. Then was added diethylether (150 ml) and the resulting mixture was washed with a 1:1 solution (150 ml) of sodium carbonate (aqueous saturated) and sodium thiosulfate (aqueous saturated) and then with sodium bicarbonate (aqueous saturated) and finally with brine. The organic phase was then dried over sodium sulfate and evaporated. Silica gel flash chromatography (pentan/ethylacetate:9/1) afforded the desired compound (0.834 g, 42%) as a white solid.

المصدر