تفاعل #1702073
ord-a8b5dcdd27e04124891270579f140223
معادلة التفاعل
المتفاعلات
الكواشف
المذيبات
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المعالجة
- 1استخلاصextracted by ethyl acetate
- 2غسيلThe organic layer was washed by water
- 3تجفيفa saturated sodium hydrogen carbonate aq. solution and a saturated saline solution, dried over magnesium sulfate
- 4تركيزconcentrated under reduced pressure
- 5أخرىThe crude product was purified by silica gel chromatography
الإجراء التجريبي
The synthesis process is as set forth in the chemical reaction formula below. The CAN in the reaction path stands for cerium ammonium nitrate. To 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-methylnaphthalene (b) (202 mg, 1.00 mol) were added acetic acid (8.2 mL) and cerium ammonium nitrate (2.40 g, 4.37 mol) followed by stirring at 100° C. for 1 hour. The reaction solution was poured into ice water and extracted by ethyl acetate. The organic layer was washed by water, a saturated sodium hydrogen carbonate aq. solution and a saturated saline solution, dried over magnesium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography using hexane/ethyl acetate (15/1) as an elution solvent. The yield was 106 mg (49%).