تفاعل #169847

معادلة التفاعل

water

4-(benzyloxy)aniline

DIEA

methyl 2-fluoro-4-(trifluoromethyl)pyridine-3-carboxylate

→

title compound

المردود 11.0%

methyl 2-{[4-(benzyloxy)phenyl]amino}-4-(trifluoromethyl)pyridine-3-carboxylate

المردود 11.0%

المذيبات

NMP

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted with EtOAc
2. 2
   أخرىThe organic layer was separated
3. 3
   غسيلwashed with water and brine
4. 4
   تجفيفdried over Na2SO4
5. 5
   تركيزconcentrated in vacuo
6. 6
   أخرىThe residue was purified by column chromatography (silica gel, EtOAc/hexane)

الإجراء التجريبي

A mixture of 4-(benzyloxy)aniline (1010 mg), DIEA (1.771 mL) and methyl 2-fluoro-4-(trifluoromethyl)pyridine-3-carboxylate (1130 mg) in NMP (10 mL) was stirred at 150° C. for 2 h and at 200° C. for 1 h under microwave irradiation. The mixture was poured into water, and the mixture was extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, EtOAc/hexane) to give the title compound (225 mg).

المصدر