تفاعل #169653

معادلة التفاعل

methyl 1-amino-4-bromo-2-naphthoate hydrobromide

N,N-dimethylformamide dimethylacetal

N,N-dimethylformamide dimethylacetal

→

methyl 4-bromo-1-{[(1E)-(dimethylamino)methylene]amino}-2-naphthoate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction was cooled to rt
2. 2
   تركيزconcentrated
3. 3
   أخرىdried

الإجراء التجريبي

A solution of methyl 1-amino-4-bromo-2-naphthoate hydrobromide (see Example 1, 3.20 g, 8.86 mmol) in N,N-dimethylformamide dimethylacetal (3.56 mL, 26.6 mmol) was heated at 100° C. for 2 h. Additional N,N-dimethylformamide dimethylacetal (1.19 mL, 8.9 mmol) was added and the solution was heated at 100° C. for an additional 3 h. The reaction was cooled to rt, concentrated, and dried to provide crude methyl 4-bromo-1-{[(1E)-(dimethylamino)methylene]amino}-2-naphthoate that gave a mass ion (ES+) of 337.1 (81Br) for [M+H]+.

المصدر