تفاعل #169520

معادلة التفاعل

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid

SOCl2

→

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonyl chloride

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe toluene and SOCl2 are distilled from the reaction mixture after 30 minutes
2. 2
   workup.ADDITIONAdditional toluene (2.5 vol) is added
3. 3
   workup.DISTILLATIONdistilled again

الإجراء التجريبي

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid (1.2 eq) is slurried in toluene (2.5 vol) and the mixture heated to 60° C. SOCl2 (1.4 eq) is added via addition funnel. The toluene and SOCl2 are distilled from the reaction mixture after 30 minutes. Additional toluene (2.5 vol) is added and distilled again.

المصدر