تفاعل #169469

معادلة التفاعل

NaOH

(4-nitro-phenyl)-acetic acid

sulphuric acid

ethanol

→

title compound

المردود 98.0%

(4-Nitro-phenyl)-acetic acid ethyl ester

المردود 98.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was heated
2. 2
   درجة الحرارةto reflux for 16 hours
3. 3
   استخلاصextracted with EtOAc (3×50 mL)
4. 4
   تجفيفThe combined organic layers were dried (Na2SO4)
5. 5
   أخرىevaporated in vacuo

الإجراء التجريبي

To a stirred solution of (4-nitro-phenyl)-acetic acid (3 g, 16.4 mmol) in ethanol (30 mL) was added sulphuric acid (1 mL) and the reaction mixture was heated to reflux for 16 hours. The reaction mixture was neutralized with 2N aq. NaOH solution and extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a light yellow oil in 98% yield, 3.4 g.

المصدر