تفاعل #169333

معادلة التفاعل

(5-bromopyridin-3-yl)(7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

ammonia

→

title compound

المردود 49.0%

(5-Aminopyridin-3-yl)(7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

المردود 49.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was evaporated in vacuo
2. 2
   استخلاصthen extracted with DCM (3×20 mL)
3. 3
   تجفيفThe combined organic extracts were dried over magnesium sulfate
4. 4
   أخرىevaporated in vacuo

الإجراء التجريبي

Copper sulfate pentahydrate (55 mg, 0.24 mmol) was added to (5-bromopyridin-3-yl)(7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (292 mg, 0.81 mmol) (see Preparation 30) and concentrated ammonia solution (20 mL). The mixture was heated in a sealed vessel at 140° C. for 17 hours. The reaction mixture was evaporated in vacuo and the residue was stirred in aqueous hydrochloric acid (10 mL, 2M) at room temperature for 17 hours. The reaction mixture was basified to pH 9 using saturated aqueous sodium carbonate then extracted with DCM (3×20 mL). The combined organic extracts were dried over magnesium sulfate and evaporated in vacuo to afford the title compound as a white solid in 49% yield, 240 mg.

المصدر