تفاعل #168912

معادلة التفاعل

4-(3-(bromomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine

4-cyanomethyl imidazole

cesium carbonate

→

product

المردود 47.0%

2-(1-(3-(2-(4-Morpholinophenylamino)pyrimidin-4-ylthio)benzyl)-1H-imidazol-4-yl)acetonitrile

المردود 47.0%

المذيبات

dimethyl formamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحIt was filtered
2. 2
   أخرىto remove any inorganic material
3. 3
   تركيزthe dimethyl formamide solution was concentrated in vacuo
4. 4
   أخرىchromatographed on the silica gel

الإجراء التجريبي

To a stirred mixture of 4-(3-(bromomethyl)phenylthio)-N-(4-morpholinophenyl)pyrimidin-2-amine (100 mg, 0.22 mmol) and 4-cyanomethyl imidazole (47 mg, 0.44 mmol) in dimethyl formamide (2 mL), was added cesium carbonate (154 mg, 0.44 mmol) in one portion. The mixture was stirred at room temperature for 16 hours. It was filtered to remove any inorganic material, and the dimethyl formamide solution was concentrated in vacuo. The residue was column chromatographed on the silica gel using methanol:dichloromethane (4:96) as eluant to give the product (50 mg, 47%).

المصدر