تفاعل #168907

ord-f5d72fcdbde44e529aa3a29392f8a97f

معادلة التفاعل

COc1ccc(Sc2ccnc(Nc3ccc(N)cc3)n2)cc1
N1-(4-(4-methoxyphenylthio)pyrimidin-2-yl)benzene-1,4-diamine
C=C(C)C(=O)O
methacrylic acid
C=C(C)C(=O)Nc1ccc(Nc2nccc(Sc3ccc(OC)cc3)n2)cc1
product
المردود 47.0%
C=C(C)C(=O)Nc1ccc(Nc2nccc(Sc3ccc(OC)cc3)n2)cc1
N-(4-(4-(4-methoxyphenylthio)pyrimidin-2-ylamino)phenyl)methacrylamide
المردود 47.0%

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

In a procedure analogous to Example 15, reaction of N1-(4-(4-methoxyphenylthio)pyrimidin-2-yl)benzene-1,4-diamine (80 mg, 0.23 mmol) and methacrylic acid (50 mg, 0.46 mmol) furnished the product (42 mg, 47%).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08846704B2uspto-grants-2014_09