تفاعل #1689

معادلة التفاعل

HCl

phenethylamine

triethylamine

methyl chloroformate

→

title compound

المردود 95.0%

N-Methoxycarbonylphenethylamine

المردود 95.0%

المذيبات

diethyl ether

THF

THF

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic layer was washed with water
2. 2
   تجفيفdried (MgSO4)
3. 3
   ترشيحfiltered
4. 4
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).

المصدر