تفاعل #168830

معادلة التفاعل

Hydrogen peroxide water

tetrahydrofuran

2-fluoro-3-methylpyridine-5-boronic acid

→

6-fluoro-5-methylpyridin-3-ol

المردود 96.0%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate
2. 2
   غسيلThe organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water
3. 3
   تجفيفdried over anhydrous sodium sulfate
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

Hydrogen peroxide water (4.37 ml, 42.8 mmol) was added to a tetrahydrofuran solution (50 ml) of 2-fluoro-3-methylpyridine-5-boronic acid (5.1 g, 32.9 mmol), and stirred overnight at room temperature. Water was added to the reaction solution, and extracted with ethyl acetate. The organic layer was washed with aqueous 5% sodium thiosulfate solution and saturated saline water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 6-fluoro-5-methylpyridin-3-ol (4.03 g, yield: 96%) as a pale yellow solid.

المصدر