تفاعل #1687667

معادلة التفاعل

product

methyl 2-hydroxy-5-(3-trimethylsilanylpropyloxy)benzoate

potassium hydroxide

hydrochloric acid

→

2-hydroxy-5-(3-trimethylsilanylpro-pyloxy)benzoic acid

المردود 64.0%

المذيبات

ethanol water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was cooled
2. 2
   أخرىThe precipitate formed
3. 3
   غسيلwas washed with water
4. 4
   أخرىdried under vacuum
5. 5
   أخرىIt was recrystallized from a 50/50 methanol/water mixture (30 ml)

الإجراء التجريبي

The product of Example 3 (3.3 g, 0.012 mol) in a 50/50 ethanol/water mixture (15 ml) was maintained at reflux for 3 hours in the presence of potassium hydroxide (2 g). The mixture was cooled and acidified to pH 1 with 10% hydrochloric acid. The precipitate formed was washed with water and dried under vacuum. It was recrystallized from a 50/50 methanol/water mixture (30 ml). 2 g (yield: 64%) of 2-hydroxy-5-(3-trimethylsilanylpro-pyloxy)benzoic acid were obtained in the form of a white powder.

المصدر