تفاعل #1687661

معادلة التفاعل

1-(5-iodopyridin-2-yl)-piperazine

3-(N,N-dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine

→

3-[4-(5-iodopyridin-2-yl)-piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine

المردود 88.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated
2. 2
   درجة الحرارةat reflux over night
3. 3
   ترشيحThe resulting solid was filtered
4. 4
   أخرىdried in vacuo

الإجراء التجريبي

To a solution of 1-(5-iodopyridin-2-yl)-piperazine (100 mg, 0.34 mmol) in toluene (2 mL) (prepared in Example 2(b)) was added 3-(N,N-dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (58 mg, 0.32 mmol) (prepared in Example 1(a)). The mixture was heated at reflux over night and then allowed to cool to room temperature. The resulting solid was filtered and dried in vacuo to give 3-[4-(5-iodopyridin-2-yl)-piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine as a colourless solid (118 mg, 79%). δH(300 MHz DMSO-d6) 2.47 (4H, m, piperazinyl), 3.45 (4H, m, piperazinyl), 3.68 (2H, s), 6.71 (1H, d, J=9), 7.05 (1H, dd, J=4.8 and 7.9), 7.39 (1H, s), 7.75 (1H, d, J=8.8), 8.06 (1H, d, J=7.8), 8.21 (1H, d, J=4.5), 8.23 (1H, s), 11.51 (1H, br s, NH)

المصدر