تفاعل #1687653

معادلة التفاعل

hydrogen chloride

p-xylene

aluminum chloride

2,5-dichlorobenzoyl chloride

→

crystals

المردود 94.2%

2,5-Dichloro-2',5'-dimethylbenzophenone

المردود 94.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the addition
2. 2
   استخلاصThe aqueous layer was extracted with ether
3. 3
   استخلاصwith ethereal extract
4. 4
   غسيلwashed with water, saturated sodium bicarbonate, brine
5. 5
   تجفيفrespectively, and then dried with magnesium sulfate
6. 6
   أخرىAfter the removal of solvent
7. 7
   أخرىthe residue was recrystallized from methanol twice

الإجراء التجريبي

To p-xylene (120 ml, 0.98 mol) was added aluminum chloride (32 g, 0.24 mol) at room temperature. To this mixture 2,5-dichlorobenzoyl chloride (30 g, 0.14 mol) was added slowly. The reaction was exothermic and hydrogen chloride evolved from the reddish solution. After the addition, the mixture was stirred for 10 min and then hydrolysed by slow addition of water. The aqueous layer was extracted with ether. The organic layer was combined with ethereal extract and washed with water, saturated sodium bicarbonate, brine, respectively, and then dried with magnesium sulfate. After the removal of solvent, the residue was recrystallized from methanol twice and then from hexane to give 36.8 g (92%) crystals (mp 58-61° C.).

المصدر