تفاعل #1687640

معادلة التفاعل

Sodium hydrogen sulfide monohydrate

3 -(3-chloro-1,2,5-oxadiazol-4-yl) pyridine

Potassium carbonate

1-bromo-3-phenylpropane

→

title compound

3-(3-(3-phenylpropylthio)-1,2,5-oxadiazol-4-yl)pyridine

المذيبات

DMF

Water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe reaction mixture was stirred for additionally 24 h
2. 2
   استخلاصextracted with ether
3. 3
   تجفيفThe combined ether phases were dried
4. 4
   أخرىevaporated
5. 5
   أخرىPurification by column chromatography (SiO2, eluent: ethyl acetate/methylene chloride (1:1))

الإجراء التجريبي

Sodium hydrogen sulfide monohydrate (0.74 g, 10.5 mmol) was added to a solution of 3 -(3-chloro-1,2,5-oxadiazol-4-yl) pyridine (1.27, 7.0 mmol) in DMF (30 ml) at room temperature and the reaction mixture was stirred for 1 h. Potassium carbonate (2.0 g, 14.5 mmol) and 1-bromo-3-phenylpropane (2.4 g, 12 mmol) were added and the reaction mixture was stirred for additionally 24 h. Water (50 ml) was added and extracted with ether. The combined ether phases were dried and evaporated. Purification by column chromatography (SiO2, eluent: ethyl acetate/methylene chloride (1:1)) gave the title compound.

المصدر