تفاعل #1687635

ord-1f3d63b3d76045508493ba53e1f22655

معادلة التفاعل

O=C([O-])/C=C/C(=O)[O-]
fumarate
Cc1cnc(-c2cccnc2)s1
88
Cc1cnc(-c2cccnc2)s1
5-Methyl-2-(3-pyridyl)-thiazole
Cc1cnc(C2=CCCN(C)C2)s1
title compound
Cc1cnc(C2=CCCN(C)C2)s1
5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىThe crude free base obtained

الإجراء التجريبي

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: USRE036374uspto-grants-1999_11