تفاعل #1687622

معادلة التفاعل

12

2-Methyl-5-(3-pyridyl)-2H-tetrazole

hydrogen chloride

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title product

المردود 26.0%

2-Methyl-(3-piperidyl)-2H-tetrazole, hydrochloride

المردود 26.0%

المذيبات

acetone

ether

ظروف التفاعل

المعالجة

1. 1
   أخرىuntil acidic reaction
2. 2
   ترشيحThe precipitate was filtered off
3. 3
   أخرىdried
4. 4
   workup.DISSOLUTIONdissolved in methanol (25 ml)
5. 5
   workup.ADDITION5% palladium on charcoal (0.6 g) was added
6. 6
   ترشيحThe catalyst was filtered off
7. 7
   أخرىthe filtrate was evaporated to dryness
8. 8
   أخرىCrystallization from ethanol

الإجراء التجريبي

To a solution of 12 (1.93 g, 0.012 mol) in acetone (50 ml) was added hydrogen chloride in ether until acidic reaction. The precipitate was filtered off, dried, and dissolved in methanol (25 ml). 5% palladium on charcoal (0.6 g) was added, and the mixture was shaked overnight under 3 atm. of hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. Crystallization from ethanol yielded 0.63 g (0.0031 mol, 26%) of title product M.P. 168°-172° C. Anal. (C7H14ClN5) C, H, N.

المصدر