تفاعل #168716

معادلة التفاعل

[1-(3-Bromo-phenyl)-2,2-difluoro-ethylidene]-carbamic acid tert-butyl ester

vinylmagnesiumbromide

NH4Cl

→

title compound

[1-(3-Bromo-phenyl)-1-difluoromethyl-allyl]-carbamic acid tert-butyl ester

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added (1 eq. per hour)
2. 2
   استخلاصThe product was extracted with TBME
3. 3
   غسيلThe organic phases were washed with water and brine
4. 4
   تجفيفdried over Na2SO4
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   أخرىThe residue was purified by automated column chromatography (cyclohexane/TBME)

الإجراء التجريبي

[1-(3-Bromo-phenyl)-2,2-difluoro-ethylidene]-carbamic acid tert-butyl ester (9.09 g, 27.2 mmol) was dissolved in toluene and cooled to −20° C. under N2. Using a syringe pump, vinylmagnesiumbromide (42.5 ml, 34.0 mmol) was added (1 eq. per hour). After 1.25 hrs no starting material was left and 218 ml half-saturated NH4Cl solution was added to the reaction. The product was extracted with TBME. The organic phases were washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by automated column chromatography (cyclohexane/TBME) to yield the title compound as a yellowish oil. 1H-NMR (600 MHz, DMSO-d6): 7.81 (br, 1H, NH), 7.52 (m, 2H), 7.35 (m, 2H), 6.48 (t, 1H, CHF2), 5.45 (d, 1H), 5.15 (d, 1H), 1.32 (s, 9H); MS: 362 [(M+H)+].

المصدر