تفاعل #1686651

معادلة التفاعل

hydrochloric acid

Lithium triethylborohydride

ethyl 1-benzoyl-4-piperidineacetate

water

→

1-benzoyl-4-(2-hydroxyethyl)piperidine

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhilst maintaining the temperature at 0°-5° C
2. 2
   درجة الحرارةto warm to 20° C.
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe combined ethyl acetate extracts were washed (dilute hydrochloric acid, brine)
5. 5
   أخرىdried
6. 6
   أخرىevaporated

الإجراء التجريبي

Lithium triethylborohydride (100 ml, 1M solution in tetrahydrofuran) was added dropwise to a solution of ethyl 1-benzoyl-4-piperidineacetate (13.8 g) in dry tetrahydrofuran (50 ml) at 0° C. under nitrogen over 20 minutes whilst maintaining the temperature at 0°-5° C. The mixture was stirred at 0° C. for a further hour, allowed to warm to 20° C. and then water (50 ml) was added slowly. The mixture was acidified with a slight excess of dilute hydrochloric acid and extracted with ethyl acetate. The combined ethyl acetate extracts were washed (dilute hydrochloric acid, brine), dried and evaporated to give 1-benzoyl-4-(2-hydroxyethyl)piperidine as an oil.

المصدر