تفاعل #168617

معادلة التفاعل

N-ethylpiperidine

(2R,3S)-3-(trityl-amino)-pentan-2-ol

DMSO

oxalyl chloride

→

title compound

(3S)-3-(Trityl-amino)-pentan-2-one

المذيبات

DCM

ether

hexane

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGwith stirring
2. 2
   workup.STIRRINGThe reaction mixture was stirred at this temperature for 4 h
3. 3
   درجة الحرارةto warm to room temperature over 16 h
4. 4
   غسيلwashed with water (200 mL)
5. 5
   استخلاصThe aqueous phase was extracted with DCM (2×50 mL)
6. 6
   غسيلthe combined organic phase washed with brine (50 mL)
7. 7
   تجفيفdried (MgSO4)
8. 8
   أخرىevaporated in vacuo
9. 9
   workup.DISSOLUTIONThe residue was dissolved in Et2O (100 mL)
10. 10
    أخرىthe solid precipitate removed by filtration
11. 11
    أخرىthe filtrate was evaporated in vacuo
12. 12
    workup.DISSOLUTIONThe residue was dissolved in hexane (50 mL)
13. 13
    أخرىthe solid precipitate removed by filtration
14. 14
    أخرىthe filtrate was evaporated in vacuo

الإجراء التجريبي

To a stirred solution of DMSO (1.95 mL, 2.8 eq, 27.48 mmol) in DCM (30 mL) under an argon atmosphere at −45° C., was added oxalyl chloride (2 M in DCM, 6.85 mL, 1.4 eq, 13.70 mmol) dropwise. The reaction mixture was stirred at −45° C. for 1 h, after which time a solution (2R,3S)-3-(trityl-amino)-pentan-2-ol (3.39 g, 1 eq, 9.83 mmol) in DCM (20 mL) was added dropwise with stirring. The reaction mixture was stirred at this temperature for 4 h, when TLC (hexane:ether; 80:20) indicated that the reaction had gone to completion. To the reaction mixture was added N-ethylpiperidine (6.71 mL, 5 eq, 48.84 mmol), and the solution allowed to warm to room temperature over 16 h. The reaction mixture was diluted with more DCM (50 mL) and washed with water (200 mL). The aqueous phase was extracted with DCM (2×50 mL), and the combined organic phase washed with brine (50 mL), dried (MgSO4) and evaporated in vacuo. The residue was dissolved in Et2O (100 mL), the solid precipitate removed by filtration and the filtrate was evaporated in vacuo. The residue was dissolved in hexane (50 mL), the solid precipitate removed by filtration and the filtrate was evaporated in vacuo to afford the title compound as a light yellow oil. Yield: 3.15 g (93%). 1H-NMR (d6-DMSO, 250 MHz): δ 0.73 (t, 3H, J=7.50 Hz, —NHCH(CH2CH3)C(CH3)O), 1.45-1.62 (m, 5H, —NHCH(CH2CH3)C(CH3)O), 3.12 (d, 1H, J=8.53 Hz, —NHCH(CH2CH3)C(CH3)O), 3.31 (m, 1H, —NHCH(CH2CH3)C(CH3)O), 7.13-7.45 (m, 15H, 3×Ph).

المصدر