تفاعل #168577

معادلة التفاعل

(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine

6-chloropurine

N-ethyldiisoproylamine

→

6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine

المذيبات

1-butanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter conventional aqueous work-up, the residue obtained
2. 2
   أخرىis crystallised from ether

الإجراء التجريبي

7.8 780 mg of (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine and 525 mg of 6-chloropurine are irradiated at 120° C. in the microwave for 6 h together with 1.2 ml of N-ethyldiisoproylamine and 40 ml of 1-butanol, during which a pressure of 10 bar arises. After conventional aqueous work-up, the residue obtained is crystallised from ether, giving 350 mg of 6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine (“A7”) as beige crystals; Rt.: 1.790 min; [M+H]+348.2; m.p. 143-144°;

المصدر