تفاعل #168570

معادلة التفاعل

6-chloropurine

2(-naphthalen-1-yloxymethyl)pyrrolidine

triethylamine

→

colourless crystals

6-[(R)-2-(naphthalen-1-yloxymethyl)pyrrolidin-1-yl]-9H-purine

المذيبات

1-butanol

ظروف التفاعل

المعالجة

1. 1
   أخرىirradiated in the microwave at 120° C. for 6 h
2. 2
   أخرىAfter removal of the solvent in vacuo
3. 3
   أخرىthe crystals which precipitate in the process
4. 4
   ترشيحare filtered off with suction
5. 5
   غسيلwashed with methanol

الإجراء التجريبي

1.6 235 mg of 6-chloropurine, 400 mg of 2(-naphthalen-1-yloxymethyl)pyrrolidine and 0.8 ml of triethylamine are dissolved in 30 ml of 1-butanol and irradiated in the microwave at 120° C. for 6 h. After removal of the solvent in vacuo, the residue is taken up in 10 ml of methanol, the crystals which precipitate in the process are filtered off with suction and washed with methanol, giving 340 mg of colourless crystals 6-[(R)-2-(naphthalen-1-yloxymethyl)pyrrolidin-1-yl]-9H-purine (“A1”); Rt.: 1.806 min; [M+H]+346; m.p. 207-208°;

المصدر