تفاعل #168536

معادلة التفاعل

2,4,5-trichloropyrimidine

7-hydroxy-2-methyl-2,3-dihydro-isoindol-1-one

caesium carbonate

→

7-(2,5-dichloro-pyrimidin-4-yloxy)-2-methyl-2,3-dihydro-isoindol-1-one

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooling bath is removed
2. 2
   استخلاصextracted three times with 75 mL ethyl acetate
3. 3
   أخرىThe combined organic phases are dried on magnesium sulphate
4. 4
   ترشيحfiltered off from the desiccant and the solvent

الإجراء التجريبي

2,4,5-trichloropyrimidine (0.20 g) and 7-hydroxy-2-methyl-2,3-dihydro-isoindol-1-one are dissolved in DCM (10 mL), cooled to 0° C. and combined with caesium carbonate (0.75 g). The cooling bath is removed and the mixture is stirred for 16 h. For working up the mixture is combined with 10% NaCl solution (100 mL) and extracted three times with 75 mL ethyl acetate. The combined organic phases are dried on magnesium sulphate, filtered off from the desiccant and the solvent is eliminated in vacuo.

المصدر