تفاعل #1683

معادلة التفاعل

trifluoroacetic acid

Boc-D-Phe-Pro-OBn

anisole

→

white powder

المردود 85.0%

D-Phe-Pro-OBn.TFA

المردود 85.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvents were evaporated in vacuo
2. 2
   workup.DISSOLUTIONthe thick oily residue was dissolved in diethyl ether (1.5 L)
3. 3
   أخرى(72 hours)
4. 4
   ترشيحThe white precipitate was filtered
5. 5
   غسيلwashed with diethyl ether (300 mL)
6. 6
   أخرىdried

الإجراء التجريبي

To a stirring solution of Boc-D-Phe-Pro-OBn (68 g, 150 mmol) in dichloromethane (50 mL) at 0° C., was added anisole (20 mL) followed by trifluoroacetic acid (400 mL). After stirring for 3 hours, the solvents were evaporated in vacuo and the thick oily residue was dissolved in diethyl ether (1.5 L) and refrigerated (72 hours). The white precipitate was filtered, washed with diethyl ether (300 mL) and dried to yield 59.4 g (85%) of white powder.

المصدر