تفاعل #1680657

معادلة التفاعل

259B

(3S,4R)-1-tert-butyl 3-ethyl 4-(allyloxycarbonyl)piperidine-1,3-dicarboxylate

TFA

→

Compound 259C

المردود 37.1%

(3S,4R)-ethyl 4-(allyloxycarbonyl)piperidine-3-carboxylate

المردود 37.1%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   workup.DISSOLUTIONThe residues was dissolved in EtOAc (20 mL)
3. 3
   غسيلwashed with saturated aqueous NaHCO3 (2×20 mL)
4. 4
   تجفيفdried (Na2SO4)
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

A solution of 259B (680 mg, 1.9 mmol) in CH2Cl2 (10 mL) was treated with TFA (1 mL) at room temperature. The reaction mixture was stirred for 16 hours, then concentrated. The residues was dissolved in EtOAc (20 mL) and washed with saturated aqueous NaHCO3 (2×20 mL), dried (Na2SO4), filtered and concentrated in vacuo to afford 170 mg of Compound 259C.

المصدر