تفاعل #1680656

معادلة التفاعل

259A

(3S,4R)-1-tert-butyl 3-ethyl 4-aminopiperidine-1,3-dicarboxylate

triethylamine

allylchloroformate

→

Compound 259B

المردود 60.4%

(3S,4R)-1-tert-butyl 3-ethyl 4-(allyloxycarbonyl)piperidine-1,3-dicarboxylate

المردود 60.4%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 0.1 N HCl (2×10 mL), 1N NaOH (2×10 mL) and brine (10 mL)
2. 2
   تجفيفThe organic layer was dried (Na2SO4)
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated in vacuo

الإجراء التجريبي

A solution of 259A (900 mg, 3.3 mmol) in CH2Cl2 (20 mL) was treated with triethylamine (0.64 mL, 4.62 mmol) and allylchloroformate (0.35 mL, 3.96 mmol) at room temperature. The mixture was stirred for four hours, then washed with 0.1 N HCl (2×10 mL), 1N NaOH (2×10 mL) and brine (10 mL). The organic layer was dried (Na2SO4), filtered and concentrated in vacuo to give 680 mg (yield: 58%) of Compound 259B as an oil.

المصدر