تفاعل #167776

معادلة التفاعل

compound 97a

tert-butyl 4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoate

hydrochloric acid

→

title compound

4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(hydroxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]-2-nitrobenzoic acid hydrochloride

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated until the crystals
2. 2
   أخرىwere precipitated
3. 3
   ترشيحthe precipitated crystals were collected by filtration

الإجراء التجريبي

To the compound 97a crude product obtained at Step (1) (10.7 g), a 4M hydrochloric acid in ethyl acetate solution (100 ml) was added, and the mixture was stirred at room temperature for 5.5 hours. The reaction mixture was concentrated until the crystals were precipitated, and the precipitated crystals were collected by filtration to obtain the title compound (1.74 g).

المصدر