تفاعل #167758

معادلة التفاعل

compound 21

tert-butyl 2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoate

hydrochloric acid

toluene

→

title compound

المردود 87.3%

2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

المردود 87.3%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitated solid was collected by filtration

الإجراء التجريبي

To the compound 21 (16 mg), 1 M hydrochloric acid in acetic acid solution was added, and the mixture was stirred at room temperature for 4 hours. To the reaction solution, toluene (5 ml) was added and the precipitated solid was collected by filtration to obtain the title compound (12.7 mg).

المصدر