تفاعل #1674557

معادلة التفاعل

methyl lithium

(±) 1-azabicyclo[3.2.1]oct-5-yl-N-methyl-N-methoxycarboxamide

(±) 1-Azabicyclo[3.2.1]oct-5-yl-N-methoxy-N-methyl carboxamide

→

(±) 5-Acetyl-1-azabicyclo[3.2.1]octane

المذيبات

diethyl ether

ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe rate of addition
2. 2
   أخرىremained below 0° C
3. 3
   أخرىwas quenched by the addition of excess glacial acetic acid
4. 4
   درجة الحرارةwhile maintaining the temperature below -10° C
5. 5
   غسيلThe ether solution was washed with a saturated solution of potassium carbonate
6. 6
   استخلاصAfter extraction of the aqueous phase with chloroform (3×200 ml) the combined organic layers
7. 7
   تجفيفwere dried over sodium sulphate
8. 8
   تركيزconcentrated in vacuo

الإجراء التجريبي

A solution of (±) 1-azabicyclo[3.2.1]oct-5-yl-N-methyl-N-methoxycarboxamide (D3) (22.0 g; 0.11 mole) in dry ether (500 ml) was cooled to -30° C. under nitrogen and treated dropwise with methyl lithium (80.0 ml of a 1.4 M solution in diethyl ether; 0.11 mole). The rate of addition was controlled to ensure that the temperature of the reaction remained below 0° C. After stirring for 1 h at -10° C. the reaction was quenched by the addition of excess glacial acetic acid, while maintaining the temperature below -10° C. The ether solution was washed with a saturated solution of potassium carbonate. After extraction of the aqueous phase with chloroform (3×200 ml) the combined organic layers were dried over sodium sulphate and concentrated in vacuo.

المصدر