تفاعل #167384

معادلة التفاعل

1-benzothiazol-6-yl-imidazolidin-2-one

2-(3-bromo-pyridin-4-yl)-propan-2-ol

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

المردود 19.0%

1-(benzo[d]thiazol-6-yl)-3-(4-(2-hydroxypropan-2-yl)pyridin-3-yl)imidazolidin-2-one

المردود 19.0%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe same reaction conditions
2. 2
   أخرىto afford the crude product
3. 3
   أخرىPurification by preparative HPLC

الإجراء التجريبي

Using the same reaction conditions as described in example 14, 1-benzothiazol-6-yl-imidazolidin-2-one (I-84b: 125 mg, 0.57 mmol) was reacted with 2-(3-bromo-pyridin-4-yl)-propan-2-ol (SM-156a: 122.7 mg, 0.57 mmol), 1,4-dioxane (5 mL), copper iodide (10.85 mg, 0.057 mmol), trans-1,2-diamino cyclohexane (19.57 mg, 0.171 mmol) and potassium phosphate (362.9 mg, 1.71 mmol) to afford the crude product. Purification by preparative HPLC afforded 38 mg of the product (19% yield).

المصدر