تفاعل #167279

معادلة التفاعل

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

1-bromo-3-trifluoromethyl-benzene

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

المردود 70.1%

1-(4-Methyl-pyridin-3-yl)-3-(3-trifluoromethyl-phenyl)-imidazolidin-2-One

المردود 70.1%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىto afford the crude product
2. 2
   أخرىPurification by column chromatography on silica gel (1.2% MeOH in CHCl3)

الإجراء التجريبي

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.847 mmol) was reacted with 1-bromo-3-trifluoromethyl-benzene (0.14 mL, 1.016 mmol), 1,4-dioxane (10 mL), copper iodide (16.13 mg, 0.0847 mmol), trans-1,2-diamino cyclohexane (0.03 mL, 0.254 mmol) and potassium phosphate (539 mg, 2.54 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.2% MeOH in CHCl3) afforded 190 mg of the product (70.11% yield).

المصدر