تفاعل #167278

معادلة التفاعل

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

bromo-benzene

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

المردود 92.3%

1-(4-Methyl-pyridin-3-yl)-3-phenyl-imidazolidin-2-one

المردود 92.3%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىto afford the crude product
2. 2
   أخرىPurification by column chromatography on silica gel (1.2-1.4% MeOH in CHCl3)

الإجراء التجريبي

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 100 mg, 0.5643 mmol) was reacted with bromo-benzene (89 mg, 0.5643 mmol), 1,4-dioxane (20 mL), copper iodide (10 mg), trans-1,2-diamino cyclohexane (20 mg) and potassium phosphate (359 mg, 1.693 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.2-1.4% MeOH in CHCl3) afforded 132 mg of the product (92.30% yield).

المصدر