تفاعل #167269

معادلة التفاعل

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

1-bromo-2,4-difluoro-benzene

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

المردود 61.2%

1-(2,4-Difluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

المردود 61.2%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىto afford the crude product
2. 2
   أخرىPurification by column chromatography on silica gel (2% MeOH in CHCl3)

الإجراء التجريبي

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8474 mmol) was reacted with 1-bromo-2,4-difluoro-benzene (0.114 mL, 1.0169 mmol), 1,4-dioxane (20 mL), copper iodide (16 mg, 0.08474 mmol), trans-1,2-diamino cyclohexane (29.4 mg, 0.254 mmol) and potassium phosphate (449.7 mg, 2.118 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 150 mg of the product (61% yield).

المصدر