تفاعل #167261

معادلة التفاعل

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

4-bromo-1-chloro-2-fluoro-benzene

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

المردود 73.3%

1-(4-Chloro-3-fluoro-phenyl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

المردود 73.3%

المذيبات

1,4-dioxane

ظروف التفاعل

الإجراء التجريبي

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.8474 mmol) was reacted with 4-bromo-1-chloro-2-fluoro-benzene (213 mg, 1.0168 mmol), 1,4-dioxane (20 mL), copper iodide (16 mg, 0.08474 mmol), trans-1,2-diamino cyclohexane (29.4 mg, 0.2542 mmol) and potassium phosphate (449.7 mg, 2.1185 mmol) to afford 190 mg of the product (73% yield).

المصدر