تفاعل #167249

معادلة التفاعل

1-(6-Fluoro-pyridin-3-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

MeOH

NaHCO3

→

product

المردود 99.0%

1-(6-Hydroxy-pyridin-3-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

المردود 99.0%

المذيبات

HCl

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe flask was heated
2. 2
   استخلاصextracted with chloroform
3. 3
   غسيلThe organic layer was washed with water, brine solution
4. 4
   أخرىdried
5. 5
   تركيزconcentrated

الإجراء التجريبي

1-(6-Fluoro-pyridin-3-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (30A: 0.1 g, 0.00036 mmol) in 5% HCl (10 mL) was added into the reaction flask and the flask was heated to reflux at 100° C. overnight. The reaction was monitored by TLC (10% MeOH in chloroform. The reaction mixture was basified with NaHCO3 solution and extracted with chloroform. The organic layer was washed with water, brine solution, dried and concentrated to afford 72 mg of the product (98.96% yield).

المصدر